期刊论文详细信息
FEBS Letters | |
Effects of the calcium ionophore A 23187 on low‐density lipoprotein processing and lipid metabolism in cultured human fibroblasts | |
Mazière, J.C.1  Mora, L.1  Polonovski, J.1  Mazière, C.1  Gardette, J.1  | |
[1] Laboratoire de Biochimie et ERA 481 du CNRS, CHU Saint-Antoine, 27 rue Chaligny, 75012 Paris, France | |
关键词: Calcium ionophore; A 23187; LDL internalization; Lipid synthesis; (Human fibroblast); | |
DOI : 10.1016/0014-5793(84)80984-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Pretreatment of cultured human fibroblasts with the calcium ionophore A 23187 resulted in a decrease in low-density lipoprotein internalization. This effect was dose-dependent and did not occur in a medium devoid of calcium. About 2-fold reduction was observed with 10−5 M A 23187. In contrast, the low-density lipoprotein binding was only slightly affected. The incorporation of [14C]acetate and [14C]oleate into all classes of lipids (sterol, triacylglycerols and phospholipids) was strikingly reduced by ionophore pretreatment.
【 授权许可】
Unknown
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