Transcription of the dystrophin gene in Duchenne muscular dystrophy muscle

FEBS Letters

Strong, Peter N.¹  Muntoni, Francesco¹ 

[1] Jerry Lewis Muscle Research Centre, Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Du Cane Road, London W12 0NN, England

关键词: Dystrophin;    Duchenne muscular dystrophy;    Polymerase chain reaction;    RNA;    PCR;    polymerase chain reaction;    DMD;    Duchenne muscular dystrophy;    BMD;    Becker muscular dystrophy;    G6PD;    glucose-6-phosphate dehydrogenase;   

DOI  :  10.1016/0014-5793(89)80896-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Dystrophin is the recently discovered defective gene product in Duchenne and Becker muscular dystrophy (DMD and BMD). Dystrophin transcripts have been amplified and identified in diagnostic needle muscle biopsy samples using the polymerase chain reaction (PCR) procedure. Using 5′- and 3′-primers, dystrophin transcripts can be detected in both DMD and BMD muscle biopsies, on either side of defined deletions within the dystrophin gene.

【 授权许可】

Unknown