Correlation between the OH bond dissociation energies of ellipticine hydroxylated derivatives and their cytotoxic properties

FEBS Letters

Auclair, C.²  Rousseau-Richard, C.¹  Martin, R.¹  Richard, C.¹ 

[1] Laboratoire de Chimie Radicalaire, UA 328 du CNRS, Université de Nancy I, BP 239, 54506 Vandeuvre Cedex France;Laboratoire de Biologie Enzymologique, INSERM U 140, CNRS LA 147, Institut Gustave Roussy, rue Camille Desmoulins, 94800 Villejuif, France

关键词: Ellipticine compound;    Bond dissociation energy;    Hydroxyl group;    Cytotoxicity;   

DOI  :  10.1016/0014-5793(89)80889-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The O−H bond dissociation energies (BDEs) of ellipticine-derived hydroxylated compounds have been evaluated by a kinetic method and are shown to correlate with the cytotoxic activity of these derivatives.

【 授权许可】

Unknown