Towards the development of antimicrobial drugs acting by inhibition of pathogen attachment to host cells: A need for polyvalency

FEBS Letters

Matrosovich, Mikhail N.¹ 

[1]Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, Moscow Region 142782, USSR

关键词: Antimicrobial drug;    Antiviral drug;    Antitumor drug;    Microbial attachment;    Cooperative binding;    Cell adhesion;    Sialic acid;    Cell adhesion inhibitor;   

DOI  :  10.1016/0014-5793(89)80879-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The development of inhibitors of microbial attachment to target cells has been proposed recently as a possible novel approach to antimicrobial chemoprophylaxis and treatment. In this paper an attempt is made to contend that such artificial inhibitors must be polyvalent, i.e. capable of binding to the pathogen or its target by multiple bonds.

【 授权许可】

Unknown