Voltage‐activated and stretch‐activated Ba2+ conducting channels in an osteoblast‐like cell line (UMR 106)

FEBS Letters

Misler, Stanley¹  Duncan, Randall¹ 

[1] Departments of Internal Medicine (Jewish Hospital), Cell Biology and Physiology and Electrical Engineering (Program in Biomedical Engineering), Washington University, St. Louis, MO, USA

关键词: Patch clamp;    Stretch-activated channel;    Ca2+ channel;    (Osteoblast);   

DOI  :  10.1016/0014-5793(89)81420-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Calcium entry may mediate osteoblast activation by calciotropic hormones or changes in electrical fields or mechanical stress in bone. Using cell-attached patch clamping techniques, we have seen two Ba²⁺ conducting channels in UMR-106 osteoblast-like cells: (i) a voltage-dependent, dihydropyridine-sensitive channel resembling L-type Ca²⁺ channels in other cells, and (ii) a stretch-activated non-selective channel resembling those involved in mechanoreception and triggering of volume regulation in other cells.

【 授权许可】

Unknown