Lipid dependence of peptide‐membrane interactions

FEBS Letters

Schwarz, Gerhard¹  Stankowski, Stefan¹ 

[1]Biocenter, University of Basel, CH-4056 Basel, Switzerland

关键词: Alamethicin;    Lipid-protein interaction;    Lipid specificity;    PC;    phosphatidylcholine;    PE;    phosphatidylethanolamine;    PG;    phosphatidylglycerol;    DEiPC;    dieicosenoyl-PC (DiC20:1);    DErPC;    dierucoyl-PC (DiC22:1);    DLiPC;    dilinoleoyl-PC (DiC18:2);    DMPC;    dimyristoyl-PC (DiC14:0);    DOPC;    dioleoyl-PC (DiC18:1);    DPaPC;    dipalmitoleoyl-PC (DiC16:1);    POPC;    1-palmitoyl-2-oleoyl-PC (C16:0/C18:1);    Chol;    cholesterol;   

DOI  :  10.1016/0014-5793(89)80795-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Membrane incorporation and aggregation of the peptide alamethicin have been investigated as a function of lipid type. Head group and acyl chain regions both contribute to modulate alamethicin incorporation. Specifically, the peptide prefers thin membranes and saturated chains; incorporation is reduced by the presence of cholesterol. Aggregation of the peptide in the bilayer is virtually insensitive to changes in lipid composition. These findings show some analogies to results obtained with intrinsic membrane proteins and cast doubt on the use of global membrane parameters for interpreting lipid-peptide interactions.

【 授权许可】

Unknown