Charybdotoxin blocks both Ca‐activated K channels and Ca‐independent voltage‐gated K channels in rat brain synaptosomes

FEBS Letters

Rogowski, R.S.¹  Schneider, M.J.¹  Krueger, B.K.¹  Blaustein, M.P.¹ 

[1] Department of Physiology, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA

关键词: Charybdotoxin;    K+ channel;    Synaptosome;    ChTX;    charybdotoxin;    α-DaTX;    α-dendrotoxin;    NTX;    noxiustoxin;    4-AP;    4-aminopyridine;    PCP;    phencyclidine (1-[1-cyclohexyl] piperazine);    TEA;    tetraethylammonium;   

DOI  :  10.1016/0014-5793(89)80771-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Charybdotoxin (ChTX), a 4.3 kDa polypeptide toxin from the venom of the scorpion Leiurus quinquestriatus, blocks both a Ca-activated K channel (IC₅₀ ≈ 15 nM) and a Ca-independent voltage-gated K channel (IC₅₀ ≈ 40 nM) in rat brain synaptosomes. These results indicate that in this preparation ChTX is not specific for the Ca-activated K channel and suggest that there may be structural homology among the toxin-binding sites on various types of K channels.

【 授权许可】

Unknown