Charybdotoxin blocks dendrotoxin‐sensitive voltage‐activated K+ channels

FEBS Letters

Maes, Pierrette²  Lazdunski, Michel³  Stansfeld, Catherine E.¹  Fagni, Laurent¹  Bidard, Jean-Noël³  Schweitz, Hugues³ 

[1] Laboratoire d'Etude des Régulations Physiologiques, 23 rue Becquerel, 67087 Strasbourg France;Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille, France;Centre de Biochimie du Centre National de la Recherche Scientifique, Parc Valrose, 06034 Nice Cedex, France

关键词: K+ channel;    Charybdotoxin;    Dendrotoxin;    Mast cell degranulating peptide;    (Dorsal root ganglia;    Rat brain);   

DOI  :  10.1016/0014-5793(89)80788-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Charybdotoxin, a short scorpion venom neurotoxin, which was thought to be specific for the blockade of Ca²⁺-activated K⁺ channels also blocks a class of voltage-sensitive K⁺ channels that are known to be the target of other peptide neurotoxins from snake and bee venoms such as dendrotoxin and MCD peptide. Charybdotoxin also inhibits ¹²⁵-dendrotoxin and ¹²⁵I-MCD peptide binding to their receptors. All these effects are observed with an IC₅₀ of about 30 nM.

【 授权许可】

Unknown