Homology between surface protein antigen genes of Streptococcus sobrinus and Streptococcus mutans

FEBS Letters

Hamada, Shigeyuki¹  Sasakawa, Chihiro³  Okahashi, Nobuo²  Koga, Toshihiko²  Yoshikawa, Masanosuke³  Takahashi, Ichiro² 

[1] Department of Oral Microbiology, Osaka University Faculty of Dentistry, Suita, Osaka 565, Japan;Department of Dental Research, National Institute of Health, Shinagawa-ku, Tokyo 141, Japan;Department of Bacteriology, The Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108 Japan

关键词: Protein antigen;    DNA homology;    (Streptococcus sobrinus;    Streptococcus mutans);   

DOI  :  10.1016/0014-5793(89)80664-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The structural gene (pag gene) for a 210 kDa protein antigen of Streptococcus sobrinus serotype g was cloned and compared with that (pac gene) of a 190 kDa protein antigen of Streptococcus mutans serotype c. Immunodiffusion analysis revealed that the product of the pag gene immunologically cross-reacted with that of the pac gene. Southern blot and nucleotide sequence analyses revealed that a significant homology existed between the middle regions of the two structural genes.

【 授权许可】

Unknown