Transforming growth factors β1 and β2 as well as milk growth factor decrease anti‐CD3‐induced proliferation of human lymphocytes without inhibiting the anti‐CD3‐mediated increase of [Ca2+]i and the activation of protein kinase C

FEBS Letters

Stoeck, Michael²  Alkan, Sefik¹  Miescher, Sylvia³  Sommermeyer, Henning³  Szamel, Marta³  Cox, David¹ 

[1] Pharmaceuticals Research Division, Ciba-Geigy Ltd, CH-4002 Basel, Switzerland;Ludwig Institute for Cancer Research, Lausanne Branch, CH-1066 Epalinges, Switzerland;Dept of Molecular Pharmacology, Hannover Medical School, D-3000 Hannover, FRG

关键词: Ca2+;    Protein kinase C;    Transforming growth factor β;   

DOI  :  10.1016/0014-5793(89)80643-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Porcine transforming growth factor 1 and 2 (pTGF-β1 and -β2) and milk growth factor (MGF) at 1 ng/ml significantly inhibited the proliferation of human lymphocytes induced by anti-CD3 antibodies. In contrast, the anti-CD3-mediated increase of intracellular Ca²⁺ and the activation and translocation of protein kinase C were not affected by the transforming growth factors.

【 授权许可】

Unknown