FEBS Letters | |
Characterization and expression of the rat heart sarcoplasmic reticulum Ca2+‐ATPase mRNA | |
Lompre, Anne-Marie1  Boheler, Kenneth R.1  Schwartz, Ketty1  de la Bastie, Diane1  | |
[1] INSERM U127, Hôpital Lariboisière, 41 Boulevard de la Chapelle, 75010 Paris, France | |
关键词: Sarcoplasmic reticulum; ATPase mRNA; Ca2+-; Nucleotide sequence; (Rat heart); Ca2+-ATPase; (Ca2+-Mg2+)-dependent ATPase; SR; sarcoplasmic reticulum; ER; endoplasmic reticulum; kb; kilobase; bp; base pair; | |
DOI : 10.1016/0014-5793(89)80010-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Sarcoplasmic reticulum Ca2+-ATPase cDNA clones have been isolated from an adult rat heart cDNA library and the nucleotide sequence of the Ca2+-ATPase mRNA determined. The sequence has an open reading frame of 997 codons. It is identical to a cDNA isolated from a rat stomach cDNA library and 90% isologous to the rabbit and human slow/ cardiac cDNAs. Nuclease S1 mapping analysis indicates that this sequence corresponds to the main Ca2+-ATPase mRNA present in heart and in slow skeletal muscle and that it is expressed in various proportions in smooth and non-muscle tissues, together with another isoform which differs from the cardiac form in the sequence of its 3′-end.
【 授权许可】
Unknown
【 预 览 】
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RO201912020292029ZK.pdf | 729KB | download |