Extremely low frequency pulsed electromagnetic fields increase interleukin‐2 (IL‐2) utilization and IL‐2 receptor expression in mitogen‐stimulated human lymphocytes from old subjects

FEBS Letters

Montagnani, G.³  Cadossi, R.⁴  Cossarizza, A.¹  Franceschi, C.¹  Paganelli, R.⁵  Bersani, F.²  Cantini, M.⁴  Monti, D.¹ 

[1] Institute of General Pathology, University of Modena, via Campi 287, 41100 Modena, Italy;Department of Physics, University of Bologna, via Irnerio 46 Bologna, Italy;Transfusional Center, USL 16, via del Pozzo 71, Modena, Italy;Center for Experimental Hematology, University of Modena, via del Pozzo 71, Modena, Italy;Clin. Medica III, Università La Sapienza, v. dell'Università 37, Roma, Italy

关键词: Pulsed electromagnetic field;    Interleukin-2;    Interleukin-2 receptor;    (Human lymphocyte);   

DOI  :  10.1016/0014-5793(89)80449-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [³H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane.

【 授权许可】

Unknown