Adenine nucleotides regulate Ca2+ transport in brain mitochondria

FEBS Letters

Rottenberg, Hagai¹  Marbach, Miriam¹ 

[1] Pathology Department, Hahnemann University, Philadelphia, PA 19102, USA

关键词: Ca2+;    Adenine nucleotide;    Spermine;    Mitochondria;   

DOI  :  10.1016/0014-5793(89)81396-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Adenine nucleotides (ADP>ATP) greatly enhance Ca²⁺ uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca²⁺ down to cellular free Ca²⁺ levels, suggesting a role for mitochondria in modulating Ca²⁺ cycles in brain cells. Analysis of the effects of various inhibitors on Ca²⁺ uptake and efflux suggest that locking the ADP/ATP translocator in its M-state stimulates electrogenic Ca²⁺ uptake and, to a lesser extent, inhibits Ca²⁺ efflux. It is suggested that this effect is due to a modulation of the surface charge on the M-side which enhances Ca²⁺ dissociation from the carriers.

【 授权许可】

Unknown