Variations in genome fragments coding for RNA polymerase in human and simian hepatitis A viruses

FEBS Letters

Kusov, Yu.Yu.¹  Chizhikov, V.E.¹  Sverdlov, E.D.¹  Blinov, V.M.¹  Andjaparidze, A.G.¹  Tsarev, S.A.¹  Balayan, M.S.¹  Vasilenko, S.K.¹ 

[1] Institute of Poliomyelitis and Viral Encephalitides, USSR Academy of Medical Sciences, M.M. Shemyakin Institute of Bioorganic Chemistry, Moscow USSR

关键词: Hepatitis A virus;    Genomic variation;    Nucleotide sequence;    Picornavirus;    RNA polymerase;    PV1;    poliovirus type 1;    CVB4;    Coxsackie virus B4;    HRV14;    human rhinovirus type 14;    HRV2;    human rhinovirus type 2;    EMCV;    encephalomyocarditis virus;    FMDV;    foot-and-mouth disease virus;    huHAV;    human hepatitis A virus;    siHAV;    simian hepatitis A virus;   

DOI  :  10.1016/0014-5793(89)81384-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The genome of hepatitis A virus (HAV) isolated from spontaneously infected African vervet monkey (Cercopithecus aethiops) has been cloned and partially sequenced. Comparison of genome fragments (1248 and 162 bp) from the 3D (RNA polymerase) region with the corresponding parts of human HAV genomes revealed a high degree of heterogeneity: there were altogether 257 nucleotide changes leading to 44 substitutions in predicted amino acid sequence, i.e. 89% amino acid identity. This divergence is considered to be significantly greater than genomic variations usually found among human HAV strains, where amino acid identity in the 3D region is over 98%.

【 授权许可】

Unknown