FEBS Letters | |
The prostate‐specific antigen gene and the human glandular kallikrein‐1 gene are tandemly located on chromosome 19 | |
van der Korput, J.A.G.M.2  Riegman, P.H.J.2  Klaassen, P.2  Trapman, J.2  Vlietstra, R.J.2  Romijn, J.C.3  van Kessel, A.Geurts1  | |
[1] Department of Cell Biology and Genetics Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands;Department of Pathology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands;Department of Urology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands | |
关键词: Kallikrein; Chromosome 19; Prostate-specific antigen; Glandular kallikrein; (Human); | |
DOI : 10.1016/0014-5793(89)81253-0 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.
【 授权许可】
Unknown
【 预 览 】
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RO201912020291867ZK.pdf | 1156KB | download |