The prostate‐specific antigen gene and the human glandular kallikrein‐1 gene are tandemly located on chromosome 19

FEBS Letters

van der Korput, J.A.G.M.²  Riegman, P.H.J.²  Klaassen, P.²  Trapman, J.²  Vlietstra, R.J.²  Romijn, J.C.³  van Kessel, A.Geurts¹ 

[1] Department of Cell Biology and Genetics Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands;Department of Pathology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands;Department of Urology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands

关键词: Kallikrein;    Chromosome 19;    Prostate-specific antigen;    Glandular kallikrein;    (Human);   

DOI  :  10.1016/0014-5793(89)81253-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using a prostate-specific antigen cDNA as a hybridization probe, clones containing the kallikrein genes encoding prostate-specific antigen, human glandular kallikrein-1 and pancreas/kidney kallikrein were isolated from a human genomic library. Clones containing the prostate-specific antigen gene and the human glandular kallikrein-1 gene overlap and span a region of about 36 kb. The two genes are aligned in a head to tail orientation at a mutual distance of 12 kb. Southern blot analysis of DNA from a panel of human-hamster hybrid cells with specific probes revealed the genes to be situated on chromosome 19. Assuming that the pancreas/kidney kallikrein gene is located in the same cluster, the distance to the prostate-specific antigen gene and the human glandular kallikrein gene must be at least 15 kb.

【 授权许可】

Unknown