Sarafotoxin receptors mediate phosphoinositide hydrolysis in various rat brain regions

FEBS Letters

Kochva, E.¹  Ambar, I.²  Bdolah, A.¹  Kloog, Y.²  Sokolovsky, M.²  Wollberg, Z.¹ 

[1] Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel;Laboratory of Neurobiochemistry, Departments of Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel

关键词: Snake venom;    Sarafotoxin;    Receptor;    Endothelin;    Phosphoinositide;    (Rat brain);    SRTX;    sarafotoxin;    PI;    phosphoinositide;    IP1;    inositol-1-phosphate;    IP2;    inositol-1;    4-bisphosphate;    IP3;    inositol-1;    4;    5-trisphosphate;    Go;    guanine nucleotide binding protein present in the brain;    Gp;    guanine nucleotide binding protein associated with phospholipase C;   

DOI  :  10.1016/0014-5793(89)80507-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sarafotoxin-b, a potent snake vasoconstrictor peptide homologous to the mammalian endothelial vasoconstrictor endothelin, induces phosphoinositide (PI) hydrolysis in various brain regions of the rat. Sarafotoxin-b induced PI hydrolysis is largely independent of extracellular Ca²⁺ and is detected in all brain regions where toxin-binding sites are found. These results point to the existence of a hitherto undetected neuroreceptor associated with the PI cycle.

【 授权许可】

Unknown