Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

FEBS Letters

Andus, Tilo³  Trullenque, Ramón¹  Fabra, Ricardo¹  Castell, José V.⁴  David, Martina⁴  Gómez-Lechón, Maria J.²  Geiger, Thomas³  Heinrich, Peter C.⁴ 

[1] Servicio de Cirugía, Hospital General de Valencia, Avda. del Cid s/n, E-46018 Valencia, Spain;Centro de Investigación, Hospital La Fe, INSALUD, Avda. de Campanar, 21, E-46009 Valencia, Spain;Medizinische Klinik der Universität Freiburg, Hugstetter Str. 55, D-7800 Freiburg, FRG;Biochemisches Institut, Universität Freiburg, Hermann-Herder-Str. 7, D-7800 Freiburg, FRG

关键词: Acute protein;    Interleukin-6;    Interleukin-1β;    Tumor necrosis factor α;    (Human hepatocyte);    rhIL-1β;    recombinant human interleukin-1β;    rhIL-6;    recombinant human interleukin-6;    rhTNFα;    recombinant human tumor necrosis factor α;   

DOI  :  10.1016/0014-5793(89)80476-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The three monokines interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL-6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory states in humans, i.e. synthesis and secretion of C-reactive protein, serum amyloid A, fibrinogen, α₁-antitrypsin, α₁-antichymotrypsin and haptoglobin are increased while albumin, transferrin and fibronectin are decreased. IL-1β as well as TNFα, although having a moderate effect on the positive acute phase proteins and inhibiting the synthesis of fibrinogen, albumin and transferrin, fail to induce serum amyloid A and C-reactive protein. These data suggest that IL-6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.

【 授权许可】

Unknown