FEBS Letters | |
Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes | |
Andus, Tilo3  Trullenque, Ramón1  Fabra, Ricardo1  Castell, José V.4  David, Martina4  Gómez-Lechón, Maria J.2  Geiger, Thomas3  Heinrich, Peter C.4  | |
[1] Servicio de Cirugía, Hospital General de Valencia, Avda. del Cid s/n, E-46018 Valencia, Spain;Centro de Investigación, Hospital La Fe, INSALUD, Avda. de Campanar, 21, E-46009 Valencia, Spain;Medizinische Klinik der Universität Freiburg, Hugstetter Str. 55, D-7800 Freiburg, FRG;Biochemisches Institut, Universität Freiburg, Hermann-Herder-Str. 7, D-7800 Freiburg, FRG | |
关键词: Acute protein; Interleukin-6; Interleukin-1β; Tumor necrosis factor α; (Human hepatocyte); rhIL-1β; recombinant human interleukin-1β; rhIL-6; recombinant human interleukin-6; rhTNFα; recombinant human tumor necrosis factor α; | |
DOI : 10.1016/0014-5793(89)80476-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The three monokines interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and interleukin-6 (IL-6) modulate acute phase plasma protein synthesis in adult human hepatocytes. Only IL-6 stimulates the synthesis of the full spectrum of acute phase proteins as seen in inflammatory states in humans, i.e. synthesis and secretion of C-reactive protein, serum amyloid A, fibrinogen, α1-antitrypsin, α1-antichymotrypsin and haptoglobin are increased while albumin, transferrin and fibronectin are decreased. IL-1β as well as TNFα, although having a moderate effect on the positive acute phase proteins and inhibiting the synthesis of fibrinogen, albumin and transferrin, fail to induce serum amyloid A and C-reactive protein. These data suggest that IL-6 plays the key role in the regulation of acute phase protein synthesis in human hepatocytes.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020291445ZK.pdf | 306KB | download |