The mitochondrial outer membrane channel, VDAC, is modulated by a soluble protein

FEBS Letters

Holden, Marcia J.¹  Colombini, Marco¹ 

[1] Laboratories of Cell Biology, Department of Zoology, University of Maryland, College Park, MD 20742, USA

关键词: Ion channel;    Voltage-dependent channel;    Mitochondria;    Regulation;    Mitochondrial membrane;    (Neurospora crassa);   

DOI  :  10.1016/0014-5793(88)81040-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mitochondrial outer membrane channel, VDAC, serves as the primary permeability pathway for metabolite flux between cytoplasmic and mitochondrial compartments. VDAC can occupy several conformational states differing in ion conductivity. Small transmembrane potentials cause transitions from open- to closed-channel conformations. A soluble mitochondrial protein enhances the channel's response to voltage by increasing the rate of channel closing; inducing the occupation of lower conductance states; and decreasing the rate of channel reopening. This protein modulator acts at very low concentrations and its role in the cell may be to regulate the permeability of the mitochondrial outer membrane by inducing channel closure.

【 授权许可】

Unknown