The Saccharomyces cerevisiae ARO1 gene An example of the co‐ordinate regulation of five enzymes on a single biosynthetic pathway

FEBS Letters

Coggins, John R.¹  Duncan, Kenneth¹  Edwards, R.Mark² 

[1] Department of Biochemistry, University of Glasgow, Glasgow G12 8QQ, Scotland;Searle Research and Development, Lane End Road, High Wycombe, Bucks HP12 4HL, England

关键词: Shikimate pathway;    Arom multifunctional enzyme;    ARO1 gene regulation;    (Saccharomyces cerevisiae);   

DOI  :  10.1016/0014-5793(88)81036-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ARO1 gene of Saccharomyces cerevisiae encodes the arom multifunctional enzyme. Specific inhibitors of amino acid biosynthesis have been used to obtain evidence that expression of a cloned ARO1 gene is regulated in response to amino acid limitation. Northern blot analysis and sequence studies indicate that ARO1 is regulated by the well characterised S. cerevisiae ‘general control’ mechanism. This provides a very economical means of simultaneously tailoring the synthesis of five shikimate pathway enzymes to the needs of the cell.

【 授权许可】

Unknown