Cellular fibronectin is induced by epidermal growth factor, but not by dexamethasone or cyclic AMP in rat liver epithelial cells

FEBS Letters

Bade, Ernesto G.²  Kornblihtt, Alberto R.¹  Seebacher, Thomas²  Manske, Marianne² 

[1] Instituto de Ingeniería Genética y Biología Molecular, Obligado 2490, Buenos Aires (1428), Argentina;Fakultät für Biologie, Universität Konstanz, Postfach 5560, D-7750 Konstanz, FRG

关键词: Epidermal growth factor;    Cell migration;    Gene expression;    mRNA splicing variant;    Extracellular matrix;    Cellular fibronectin;    (Rat liver epithelial cell);   

DOI  :  10.1016/0014-5793(88)80556-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Epidermal growth factor (EGF) induces fibronectin (FN) and FN mRNA in rat liver epithelial cells, under conditions where the factor also induces the cells to migrate. Newly synthesized protein is secreted into the medium and deposited as substratum-bound extracellular matrix. The levels of mRNA and the amount of protein synthesized are not influenced by cyclic AMP or dexamethasone, factors that have been found to modulate FN expression in other cells. However, the cells are sensitive to the factors, suggesting a cell-specific regulation. The EGF-induced RNA contains the sequences EIIIA and EIIIB characteristic of cellular fibronectin.

【 授权许可】

Unknown