Inhibition of HIV replication by amino‐sugar derivatives

FEBS Letters

Ramsden, Nigel G.²  Fellows, Linda E.²  Jacob, Gary S.⁵  Petursson, Sigthor²  Son, Jong Chan²  Namgoong, Sung K.²  Dwek, Raymond A.³  Witty, David R.²  Wilson, Francis²  Smith, Paul W.²  Tyms, A.S.¹  Fleet, George W.J.²  Rademacher, Thomas W.³  Karpas, Abraham⁴ 

[1] Division of Virology, Department of Medical Microbiology, St. Mary's Hospital Medical School, London W2 pq, England;Dyson Perrins Laboratory, Department of Organic Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QY England;Glycobiology Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU England;Clinical School, Department of Haematological Medicine, University of Cambridge, Hills Road, Cambridge CB2 2QL, Jodrell Laboratory, Royal Laboratory, Royal Botanic Gardens, Kew, Richmond TW9 3DS England;Department of Molecular and Cell Biology, G.D. Searle & Co., St. Louis, MO 63198, USA

关键词: AIDS;    HIV;    Glycosidase inhibitor;    Amino-sugar;    Glycosylation;   

DOI  :  10.1016/0014-5793(88)80185-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120–8124; (1987) Nature 330, 74–77; (1987) Lancet i, 1025–1026]. They are thought to act by inhibiting α-glucosidase I, an enzyme involved in the processing of N-linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino-sugar derivatives as inhibition of HIV cytopathicity. Several α-glucosidase inhibitors and α-fucosidase inhibitors were found to be active at concentrations which were non-cytotoxic.

【 授权许可】

Unknown