Early cortical plate specific glycoprotein in a marsupial species belongs to the same family as fetuin and α2HS glycoprotein

FEBS Letters

Dziegielewska, K.M.²  Christie, D.L.¹  Jones, S.E.²  Szelke, M.³  Saunders, N.R.²  Sueiras-Diaz, J.³ 

[1] Department of Biochemistry, University of Auckland, Private Bag, Auckland, New Zealand;Department of Physiology and Pharmacology and The Wessex Area Neurosciences Group, Bassett Crescent East, The University, Southampton SO9 3TU, England;Ferring Research Institute, Chilworth, Southampton SO1 7NP, England

关键词: α2HS glycoprotein;    Fetuin;    Brain development;    (Marsupial);   

DOI  :  10.1016/0014-5793(88)80067-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two related glycoproteins, fetuin in species of the order Artiodactyla (cattle, sheep, pig) and α₂HS glycoprotein in the human [(1987) Cell Tissue Res. 248, 33–41] have a very specific distribution in the developing brain. We have isolated and determined the first 15 N-terminal residues of a similarly distributed glycoprotein in the developing brain of the tammar wallaby (Macropus eugenii). The degree of homology is the same between wallaby glycoprotein and α₂HS glycoprotein as between fetuin and α₂HS glycoprotein (46%). Antibodies made to synthetic peptides of fetuin were used to identify the wallaby glycoprotein. A polyclonal antibody to the purified glycoprotein was used for immunocytochemical identification of brain cells positive for this protein.

【 授权许可】

Unknown