Differential splicing in the 3′ non‐coding region of rat cytochrome P‐452 (P450 IVA1) mRNA

FEBS Letters

Goldfarb, Peter S.¹  Dale, Jeremy W.¹  Gibson, G.Gordon¹  Earnshaw, David¹ 

[1] Departments of Biochemistry and Microbiology, University of Surrey, Guildford GU2 5XH, Surrey, England

关键词: Cytochrome P-450;    Clofibrate;    Gene regulation;    Differential splicing;   

DOI  :  10.1016/0014-5793(88)80055-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The gene coding for the clofibrate-induced cytochrome P-452 has been isolated from a cDNA library and a full-length cDNA clone sequenced. The sequence was identical with that reported by Hardwick et al. [(1987) J. Biol. Chem. 262, 801–810] apart from the presence of an additional 75 nucleotides inserted adjacent to the 3′-end of the coding region. Northern blot analysis indicates that this is probably a consequence of differential splicing, which may be relevant to the tissue-specific regulation of this gene.

【 授权许可】

Unknown