Na‐pump activity in rat kidney cortex cells and its relationship with the cell volume

FEBS Letters

Perrone, Trina M.¹  Proverbio, Fulgencio¹  Matteo, Rosalía G.¹  Marín, Reinaldo¹  Proverbio, Teresa¹ 

[1] Centro de Biofísica y Bioquímica, Instituto Venezolano de Investigaciones Científicas (IVIC), AP 21827, Caracas 1020A, Venezuela

关键词: Na+ pump;    Na+-ATPase;    Cell volume;    (Rat kidney cortex);   

DOI  :  10.1016/0014-5793(88)80046-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The present work was undertaken to evaluate whether changes in cell water content of rat kidney cortex cells can modulate the transport activity of the ouabain-insensitive Na pump as they modulate the ouabain-insensitive Na⁺-ATPase. It was found that there is a close relationship between the cell volume and activity of the Na pump, whereas Na,K-pump activity is not affected by variations in cell volume. When the cell water content is low, Na-pump activity (Na⁺ transport and Na⁺-ATPase activity) is minimal. Increases in cell water content produce a concomitant increase in Na-pump activity.

【 授权许可】

Unknown