Effects of t‐butyl‐4‐hydroxyanisole and other phenolic antioxidants on tumoral cells and Trypanosoma parasites

FEBS Letters

Morello, A.²  Repetto, Y.¹  Aldunate, J.¹  Fones, E.¹  Coloma, L.¹  Letelier, M.E.¹  Ferreira, J.¹ 

[1] Department ofBiological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;Department of Biochemistry and Chemistry, Faculty of Medicine, University of Chile, PO Box 70086, Santiago 7, Chile

关键词: Respiration inhibition;    t-Butyl-4-hydroxyanisole;    (Trypanosoma cruzi;    Trypanosoma brucei;    Tumor cell);   

DOI  :  10.1016/0014-5793(88)80143-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The antioxidant food additives 2(3)-tert-butyl-4-hydroxyanisole (BHA), 2,6-di(tert-butyl)-p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. The I ₅₀ values for growth and oxygen uptake with BHA were 0.284 and 0.400 and for BHT 0.083 and 0.235 mM, respectively. Moreover, BHA inhibited the respiration of several tumor cells, as well as of the procyclic and bloodstream trypomastigote forms of T. brucei brucei, with I ₅₀ in the range 0.29–0.52 mM. Inhibition of the parasites' oxygen uptake by BHA was not of the pure Michaelis-Menten type, but may be of a mixed form. It is postulated that these compounds are inhibitors because they resemble ubiquinone.

【 授权许可】

Unknown