t‐Butyl‐4‐hydroxyanisole, a novel respiratory chain inhibitor

FEBS Letters

Morello, A.¹  Repetto, Y.¹  Aldunate, J.¹  Letelier, M.E.¹  Ferreira, J.¹ 

[1] Department of Biochemistry, Faculty of Medicine. University of Chile, PO Box 70086, Santiago 7, Chile

关键词: (Trypanosoma cruzi) t-Butyl-4-hydroxyanisole Respiratory chain inhibition Chagas' disease;   

DOI  :  10.1016/0014-5793(86)80180-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

t-Butyl-4-hydroxyanisole, an antioxidant food additive, inhibited the growth of Trypanosoma cruzi by almost 100% at 0.5 mM concentration. This compound inhibited 70% of oxygen consumption of epimastigotes. The redox level of NAD(P) was shifted to a more reduced state and inversely the redox level ofcytochrome b changed to a more oxidized state. This hydroxyanisole thus is a new electron transport chain inhibitor. This compound and related ones, or the respiratory chain of T. cruzi, may be important in the design of antichagasic drugs.

【 授权许可】

Unknown