FEBS Letters | |
Redox transformations of quinone antitumor drugs in liver microsomes | |
Rumyantseva, G.V.1  Weiner, L.M.1  | |
[1] Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, USSR | |
关键词: Anthracycline antibiotic; Spin trapping; Hydroxyl radical; ESR; | |
DOI : 10.1016/0014-5793(88)80138-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The hydroxyl radical has been spin trapped in microsomal and purified NADPH-cytochrome P-450 reductase systems in the presence of adriamycin, daunomycin and mitomycin C. The presence of a lag period in quinone-stimulated spin-adduct formation is associated with oxygen removal upon its reduction to H2O2. The hydroxy radical generation has been stimulated by the Fe-EDTA complex and completely inhibited by catalase. The mechanism of redox transformations of anthracyclines in a microsomal system has been proposed The single electron reduced quinone-containing anticancer antibiotics play the following roles: (i) they reduce oxygen to H2O2 and (ii) they reduce the ferric ions necessary for H2O2 decomposition with hydroxyl radical formation.
【 授权许可】
Unknown
【 预 览 】
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