期刊论文详细信息
FEBS Letters | |
One‐electron reduction of an anthracycline antibiotic carminomycin by a human erythrocyte redox chain | |
Peskin, Alexander V.1  Bartosz, Grzegorz1  | |
[1] Chair of Biophysics, University of Lodz, 90-237 Lodz, Poland | |
关键词: NAD(P)H-dependent reduction; Erythrocyte membrane; Anthracycline antibiotic; Free radical; ESR; | |
DOI : 10.1016/0014-5793(87)81218-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Human erythrocyte membranes catalyse the NAD(P)H-dependent generation of the semiquinone of an adriamycin-type antibiotic carminomycin under anaerobic conditions. The maximal yield of the antibiotic radical is about 4-fold higher in the presence of NADPH than of NADH. The possible significance of the antibiotic reduction to the semiquinone by a human erythrocyte membrane redox chain for the clinical usage of these antibiotics is discussed.
【 授权许可】
Unknown
【 预 览 】
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