One‐electron reduction of an anthracycline antibiotic carminomycin by a human erythrocyte redox chain

FEBS Letters

Peskin, Alexander V.¹  Bartosz, Grzegorz¹ 

[1] Chair of Biophysics, University of Lodz, 90-237 Lodz, Poland

关键词: NAD(P)H-dependent reduction;    Erythrocyte membrane;    Anthracycline antibiotic;    Free radical;    ESR;   

DOI  :  10.1016/0014-5793(87)81218-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human erythrocyte membranes catalyse the NAD(P)H-dependent generation of the semiquinone of an adriamycin-type antibiotic carminomycin under anaerobic conditions. The maximal yield of the antibiotic radical is about 4-fold higher in the presence of NADPH than of NADH. The possible significance of the antibiotic reduction to the semiquinone by a human erythrocyte membrane redox chain for the clinical usage of these antibiotics is discussed.

【 授权许可】

Unknown