Pertussis toxin stimulates delayed‐onset, Ca2+‐dependent catecholamine release and the ADP‐ribosylation of a 40 kDa protein in bovine adrenal chromaffin cells

FEBS Letters

Pollard, Harvey B.¹  Brocklehurst, Keith W.¹ 

[1] Laboratory of Cell Biology and Genetics, Building 8, Room 405, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA

关键词: Exocytosis;    Pertussis toxin;    G-protein;    ADP-ribosylation;    Stimulus-secretion coupling;    (Adrenal medulla);   

DOI  :  10.1016/0014-5793(88)80133-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pertussis toxin was found to stimulate catecholamine release from bovine adrenal chromaffin cells in a Ca²⁺ -dependent manner and in the absence of any stimulatory or inhibitory agonists for this cell. The release of catecholamine was associated with the ADP-ribosylation of an approx. 40 kDa protein present in the total membrane fraction. These results are consistent with the existence of an exocytosis-linked G-protein.

【 授权许可】

Unknown