Selective inhibition of oat glutathione‐S‐transferase activity by tetrapyrroles

FEBS Letters

Singh, Bal Ram¹  Shaw, Robert W.¹ 

[1] Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA

关键词: Bilirubin;    Biliverdin;    Chlorophyllin;    Glutathione-S-transferase;    Hemin;    Enzyme inhibition;    Tetrapyrrole;    (Oat);   

DOI  :  10.1016/0014-5793(88)80120-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Inhibition of glutathione-S-transferase activity by various tetrapyrroles (bilirubin, biliverdin, chlorophyllin and hemin) has been studied. Addition of 77 μM bilirubin or biliverdin inhibited glutathione-S-transferase activity only by 15–19% whereas 77μM chlorophyllin or hemin inhibited the enzyme activity by 83–86%. The data suggest that oat glutathione-S-transferases can distinguish between open and closed tetrapyrroles. Possible physiological significance of the observed results is discussed.

【 授权许可】

Unknown