Long‐term ingestion of ammonium inhibits lysosomal proteolysis in rat liver

FEBS Letters

Wallace, Ruth¹  Felipo, Vicente¹  Miñana, María-Dolores¹  Grisolía, Santiago¹ 

[1] Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC, Amadeo de Saboya, 4, 46010 Valencia, Spain

关键词: Ammonia;    Lysosomal proteolysis;   

DOI  :  10.1016/0014-5793(88)81336-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A standard diet was supplemented with ammonium acetate (20%, w/w). The effect on liver protein degradation of oral administration of the ammonium diet to rats for 6 weeks has been studied. It is shown that lysosomal proteolysis is markedly decreased (by 62%) while non-lysosomal proteolysis is inhibited by 11%. This is the first report showing that ammonium ingestion inhibits liver proteolysis.

【 授权许可】

Unknown