A model for cell type localization in the migrating slug of Dictyostelium discoideum based on differential chemotactic sensitivity to cAMP and differential sensitivity to suppression of chemotaxis by ammonia

Journal of biosciences

Caroline Zawilski¹  Ira N Feit1¹  Jeffrey Pawlikowski¹ 

[1] Franklin and Marshall College, Lancaster, PA 17603, USA$$

关键词: Ammonia;    chemotaxis;    cyclic AMP (cAMP);    Dictyostelium discoideum;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

The three basic cell types in the migrating slug of Dictyostelium discoideum show differential chemotactic response to cyclic AMP (cAMP) and differential sensitivity to suppression of the chemotaxis by ammonia. The values of these parameters indicate a progressive maturation of chemotactic properties during the transdifferentiation of slug cell types. We present a model that explains the localization of the three cell types within the slug based on these chemotactic differences and on the maturation of their chemotactic properties.

【 授权许可】

Unknown