Vitamin E and selenium regulate balance between β‐adrenergic and muscarinic responses in rat lungs

FEBS Letters

Doelman, C.J.A.¹  Timmerman, H.¹  Kramer, K.¹  Bast, A.¹ 

[1] Dept of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands

关键词: Vitamin E;    Selenium;    β-Adrenergic receptor;    Muscarinic receptor;    (Lung);   

DOI  :  10.1016/0014-5793(88)80476-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of hydrogen peroxide on the β-adrenergic and muscarinic responses of the rat trachea muscle were studied in vitro, after feeding rats, for 6 weeks, either a diet deficient in vitamin E and selenium or a control diet. In the control situation after incubation with 1 mM hydrogen peroxide for 30 min, a reduction of the maximal response to methacholine of 39% occurred whereas no pD ₂ shift could be demonstrated. Moreover, no response to isoprenaline after precontraction with 3 × 10⁻⁷ M methacholine was left. In the deficient situation, we found a reduction to 64% of the response to methacholine after incubation with 1 mM hydrogen peroxide. Again isoprenaline became inactive, i.e. no relaxation with isoprenaline was observed after precontraction with 3 × 10⁻⁷ M methacholine. We therefore conclude that vitamin E and selenium protect against oxidative stress in lung tissue and thus regulate the (patho-) physiological balance between adrenergic and muscarinic responses.

【 授权许可】

Unknown