Family of human Na+,K+‐ATPase genes Structure of the gene for the catalytic subunit (αIII‐form) and its relationship with structural features of the protein

FEBS Letters

Kostina, M.B.¹  Sverdlov, E.D.¹  Modyanov, N.N.¹  Monastyrskaya, G.S.¹  Kiyatkin, N.I.¹  Ushkaryov, Yu.A.¹  Smirnov, Yu.V.¹  Ovchinnikov, Yu.A.¹  Allikmets, R.L.¹  Melkov, A.M.¹  Grishin, A.V.¹  Malyshev, I.V.¹  Dulubova, I.E.¹  Broude, N.E.¹ 

[1] Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, 117871 Moscow, USSR

关键词: Na+;    K+-ATPase;    Catalytic subunit;    Gene sequence;    Exon/intron structure;    Protein spatial organization;   

DOI  :  10.1016/0014-5793(88)81361-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The primary structure of a gene of the Na⁺,K⁺-ATPase multigenic family in the human genome has been determined. The gene corresponds to a hypothetical αIII-form of the enzyme catalytic subunit. The gene comprises over 25000 bp, and its protein coding region includes 23 exons and 22 introns. Possible correlation between structural features of the protein and location of introns in the gene are discussed.

【 授权许可】

Unknown