Periportal and perivenous hepatocytes respond equally to glycogenolytic agonists

FEBS Letters

Keppens, Stefaan¹  De Wulf, Henri¹ 

[1] Afdeling Biochemie, Campus Gasthuisberg, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

关键词: Glycogenolysis;    Metabolic zonation;    Hormone;    (Hepatocyte);   

DOI  :  10.1016/0014-5793(88)81353-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have used the technique of short-term infusion with digitonin to obtain hepatocytes originating either from the periportal or the perivenous zone of the liver acinus [(1985) Biochem. J. 229, 221–226]. Total glycogen phosphorylase content and sensitivity to cyclic AMP-dependent and calcium-mediated glycogenolytic agonists were very similar for both cell sub-populations and did not differ from the values obtained for control cells. We conclude therefore that there is an apparent absence of metabolic zonation as far as receptor-mediated glycogenolysis and glycogenolytic potency is concerned.

【 授权许可】

Unknown