Developmentally regulated alternative splicing of brain myelin‐associated glycoprotein mRNA is lacking in the quaking mouse

FEBS Letters

Sato, Shuzo¹  Kurihara, Tadashi²  Inuzuka, Takashi¹  Miyatake, Tadashi¹  Takahashi, Yasuo²  Fujita, Nobuya¹ 

[1] Departments of Neurology Brain Research Institute, Niigata University, Niigata 951, Japan;Neuropharmacology, Brain Research Institute, Niigata University, Niigata 951, Japan

关键词: Myelin;    Myelin-associated glycoprotein;    Alternative splicing;    Dysmyelination;    Developmental regulation;    (Quaking mouse);   

DOI  :  10.1016/0014-5793(88)80762-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is presented that expression of the two myelin-associated glycoprotein mRNAs is developmentally regulated in mouse brain. In quaking mouse, the mRNA without a 45-nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45-nucleotide exon portion is lacking in quaking mouse.

【 授权许可】

Unknown