Anthraquinone inhibitors of photosystem II electron transport

FEBS Letters

Oettmeier, Walter¹  Masson, Klaus¹  Donner, Andreas¹ 

[1] Lehrstuhl Biochemie der Pflanzen, Fakultät für Biologie, Ruhr-Universität, Postfach 10 21 48, D-4630 Bochum 1, FRG

关键词: 9;    10-Anthraquinone;    Photosystem II;    Binding characteristic;    Covalent modification;    chl;    chlorophyll;    DCIP;    dichlorophenolin-dophenol;    DNP-INT;    2-iodo-2′;    4;    4′-trinitro-3-methyl-6-iso-propyldiphenyl ether;    QSAR;    quantitative structure-activity relationship;   

DOI  :  10.1016/0014-5793(88)80743-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Various substituted 9,10-anthraquinones were tested for their inhibitory activity on photosystem II electron transport. Maximal inhibitory activity was achieved if the positions adjacent to one of the quinone carbonyl groups were unsubstituted or substituted by hydroxyl groups only. The best anthraquinone type inhibitor found so far was 2,3,4-trichloro-1-hydroxy-anthraquinone with a pI ₅₀ value of 7.75. This is well comparable to the most powerful known photosystem II inhibitors. As studied by binding experiments with 1-[¹⁴C]methoxy-anthraquinone, after covalent modification of thylakoids with azido-atrazine, anthraquinones bind at the photosystem II D1 protein. Their orientation within the binding niche seems to be different from that of other photosystem II inhibitors.

【 授权许可】

Unknown