Activation of a brain‐specific protein kinase C subspecies in the presence of phosphatidylethanol

FEBS Letters

Satoh, Tadashi²  Kosaka, Yoshiyuki¹  Sekiguchi, Kazuo¹  Nakano, Yoshio²  Shearman, Mark S.¹  Kikkawa, Ushio¹  Asaoka, Yoshinori¹  Nishizuka, Yasutomi¹ 

[1] Department of Biochemistry, Kobe University School of Medicine, Kobe 650 Japan;Oil & Fats Research Laboratories, Nippon Oil & Fats Company, Amagasaki 660, Japan

关键词: Protein kinase C;    Phosphatidylethanol;    Ethanol;    Phospholipase D;   

DOI  :  10.1016/0014-5793(88)80735-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Protein kinase C (PKC) is normally activated by diacylglycerol in the presence of Ca²⁺ and phosphatidylserine. At physiological concentrations of Ca²⁺, however, phosphatidylethanol, a product of the phospholipase D-catalyzed transphosphatidylation reaction between membrane phospholipids and ethanol, can replace phosphatidylserine, and activate PKC. This mode of activation is most effective for the γ-subspecies, which is expressed only in central nervous tissue. Phosphatidylmethanol is also effective to some extent. Consideration of these results suggests the possibility that ethanol may exert some effect on signal transduction in this tissue via changes in protein phosphorylation.

【 授权许可】

Unknown