The IFI‐56K and IFI‐54K interferon‐inducible human genes belong to the same gene family

FEBS Letters

Huez, Georges A.¹  Wathelet, Marc G.¹  Clauss, Isabelle M.¹  Content, Jean² 

[1] Département de Biologie Moléculaire, Université Libre de Bruxelles, 67 rue des Chevaux, B-1640 Rhode-St-Genèse, Belgium;Institut Pasteur du Brabant, 642 rue Engeland, B-1180 Bruxelles, Belgium

关键词: Poly(rI)·poly(rC)-inducible gene;    Virus-inducible gene;    Sequence comparison;    Needleman-Wunsch-Sellers algorithm;    IFN;    interferon;    poly(rI)·poly(rC);    polyriboinosinic-polyribocytidylic acid;   

DOI  :  10.1016/0014-5793(88)80724-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The IFI-56K and IFI-54K human genes are coordinately regulated by interferon, double-stranded RNA and viruses in a number of cell lines. These genes encode polypeptides of 56 and 54 kDa, respectively, whose function remains to be determined. We analysed the possible structural relatedness between these syntenic and similarly regulated genes. We found that they are very closely related at the protein, mRNA and promoter levels. This suggests that the IFI-56K and IFI-54K genes are members of a gene family, which probably arose from duplication of an ancestor gene.

【 授权许可】

Unknown