The amino‐terminal domain of thrombomodulin and pancreatic stone protein are homologous with lectins

FEBS Letters

Petersen, Torben E.¹ 

[1]Department of Molecular Biology and Plant Physiology, University of Aarhus, DK-8000 Aarhus, Denmark

关键词: Sequence homology;    Thrombomodulin;    Pancreatic stone protein;    Lectin;   

DOI  :  10.1016/0014-5793(88)80700-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Amino acid sequence alignment of the amino-terminal domain of thrombomodulin and pancreatic stone protein with the hepatic asialoglycoprotein receptor shows that these proteins are homologous. From the known disulfide bridge pattern of other proteins belonging to the same family two disulfide bonds can be predicted. The homology raises the question whether the amino-terminal part of thrombomodulin and the pancreatic protein binds carbohydrate or perhaps like tetranectin have a specific affinity for other proteins.

【 授权许可】

Unknown