Activation of an S6 kinase from rat astroglial cells by cAMP

FEBS Letters

Pierre, Michel¹  Jacquemin, Claude¹  Pomerance, Martine¹  Toru-Delbauffe, Danièle¹  Matricon, Carole¹  Gavaret, Jean-Michel¹ 

[1] Unité de Recherche sur la Glande Thyroïde et la Régulation Hormonale, INSERM Unité 96, 78, rue du Génŕal Leclerc, 94275 Le Kremlin-Bicêtre, France

关键词: Astrocyte;    cyclic AMP;    Mitogen stimulation;    Protein S6 kinase;    Enzyme activation;   

DOI  :  10.1016/0014-5793(88)80002-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Forskolin and isoproterenol, agonists of adenylate cyclase activity, and dibutyryl cyclic AMP, stimulated an S6 kinase activity in astroglial cells. This activity was insensitive to the thermostable inhibitor of cyclic AMP-dependent protein kinase and had the same behaviour on a DEAE-Sephacel column as the mitogen stimulated S6 kinase. These observations support the idea that the cyclic AMP cascade, as well as various growth factors, can activate S6 kinase.

【 授权许可】

Unknown