Identification of novel GTP‐binding proteins in the human neutrophil

FEBS Letters

Bokoch, Gary M.¹  Parkos, Charles A.¹ 

[1] Department of Immunology, Research Institute of Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA

关键词: GTP-binding protein;    Neutrophil;    Signal transduction;   

DOI  :  10.1016/0014-5793(88)81415-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We describe here the existence of previously undescribed GTP-binding proteins within the human neutrophil. These proteins specifically bind guanine nucleotides under conditions in which the previously characterized G-proteins are unable to bind. We have partially purified these proteins and present both functional and immunologic data which indicate that they are unrelated to G_n, the major neutrophil pertussis toxin substrate. An additional protein, of apparent molecular mass 22 kDa, may be related to the ras G-protein family. Analysis of the structural and functional characteristics of these novel proteins will promote a better understanding of the process of neutrophil activation.

【 授权许可】

Unknown