期刊论文详细信息
FEBS Letters | |
A two‐dimensional NMR study of the antimicrobial peptide magainin 2 | |
Bax, Ad1  Zasloff, Michael2  Marion, Dominique1  | |
[1] Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA;Human Genetics Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA | |
关键词: Peptide; α-Helix; Magainin; 2D NMR; NOESY; 2D; two-dimensional; NOE; nuclear Overhauser effect; NOESY; NOE spectroscopy; HOHAHA; homonuclear Hartmann-Hahn spectroscopy; TFE; trifluoroethanol; | |
DOI : 10.1016/0014-5793(88)81405-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Using two-dimensional NMR spectroscopy, a complete 1H resonance assignment has been obtained for the peptide magaining 2 recently isolated from Xenopus laevis. It is demonstrated that this peptide adopts an α-helical structure with amphiphilic character when dissolved in a mixture of trifluoroethanol (TFE) and H2O. The transition to the α-helical conformation occurs at very low concentrations of TFE.
【 授权许可】
Unknown
【 预 览 】
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RO201912020290132ZK.pdf | 364KB | download |