Uncoupling effects of local anesthetics on rat liver mitochondria

FEBS Letters

Erny, P.¹  Dabadie, P.¹  Mazat, J.-P.¹  Bendriss, P.¹ 

[1] Université Bordeaux II,CNRS, 1, rue Camille Saint-Saëns, F-33077 Bordeaux Cedex, France

关键词: Mitochondria;    Uncoupler;    Local anesthetic;    Electron transport chain;    (Rat liver);    CCCP;    carbonyl cyanide m-chloro-phenylhydrazone;    TPB−;    tetraphenylboron;    bupivacaine;    1-butyl-N-(2;    6-dimethylphenyl)-2-piperidinecarboxamide;    lidocaine;    2-(diethylamino)-N-(2;    6-dimethyl-phenyl)acetamide;   

DOI  :  10.1016/0014-5793(87)80554-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We demonstrate in this paper that bupivacaine, a local anesthetic, can act alone as an uncoupler of rat liver mitochondria. It stimulates state 4 respiration, induces a swelling in potassium acetate (in the presence of valinomycin), and collapses the transmembrane potential. Lidocaine, another local anesthetic, requires the presence of a lipophilic anion such as TPB⁻ to produce the same effects. TPB⁻ can also reinforce the action of bupivacaine. These differences in action of the two local anesthetics can be explained by the difference in their liposolubility.

【 授权许可】

Unknown