Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement

Redox Biology

Andrea Braganza¹  Deirdre Nolfi-Donegan²  Sruti Shiva² 

[1] Department of Pediatrics, Division of Hematology/Oncology, Children's Hospital of Pittsburgh, Pittsburgh, PA, 15224, USA;Heart, Lung, Blood Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15261, USA;

关键词: Electron transport chain;    Mitochondrial reactive oxygen species;    Mitochondria;    Oxidative phosphorylation;   

DOI  :  

来源: DOAJ

【 摘 要 】

The mitochondrial electron transport chain utilizes a series of electron transfer reactions to generate cellular ATP through oxidative phosphorylation. A consequence of electron transfer is the generation of reactive oxygen species (ROS), which contributes to both homeostatic signaling as well as oxidative stress during pathology. In this graphical review we provide an overview of oxidative phosphorylation and its inter-relationship with ROS production by the electron transport chain. We also outline traditional and novel translational methodology for assessing mitochondrial energetics in health and disease.

【 授权许可】

Unknown