Effect of dibutyryl cyclic AMP and theophylline on lipoprotein lipase secretion by human monocyte‐derived macrophages

FEBS Letters

Maziere, J.C.¹  Picard, J.²  Bertrand, J.²  Margelin, D.²  Gardette, J.² 

[1] CNRS UA 524, Faculté de Médecine Saint-Antoine, Paris, France;Laboratoire de Biochimie, INSERM U181, Faculté de Médecine Saint-Antoine, Paris, France

关键词: Lipoprotein lipase;    cyclic AMP;    Enzyme synthesis;    (Human monocyte-derived macrophage);   

DOI  :  10.1016/0014-5793(87)81153-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of dibutyryl cyclic AMP and theophylline on lipoprotein lipase secretion was investigated after a 24 h pretreatment of human monocyte-derived macrophages. Both the effectors decreased in a dose-dependent manner the enzyme activity recovered in the culture medium. The decrease in lipoprotein lipase activity appeared to be related to reduced enzyme synthesis without apparent modification of its stability and half-life and was conversely associated with an increase of lysosomal acid hydrolase activities. This effect was reversible on removal of the nucleotide. The present findings suggest that cyclic AMP may play a role in lipoprotein lipase expression in human macrophages and therefore may participate in the regulation of lipoprotein uptake by these cells, which are strongly implicated in the atherogenic process.

【 授权许可】

Unknown