Lipoxin A augments release of thromboxane from human polymorphonuclear leukocyte suspensions

FEBS Letters

Cancelli, Alessandro¹  Reale, Marcella¹  Conti, Pio¹  Angeletti, Pietro U.¹ 

[1] Cattedra di Immunologia, Istituto di Medicina Sperimentale, Universitá di Chieti, Via dei Vestini, 66100 Chieti, Italy

关键词: Lipoxin;    Thromboxane;    Indomethacin;    Polymorphonuclear leukocyte;    LXA;    lipoxin A;    Tx;    thromboxane;    PMN;    polymorphonuclear;    A2318;    ionophore A23187;    PG;    prostaglandin;    I;    indomethacin P;    proglumetacin;   

DOI  :  10.1016/0014-5793(87)81139-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipoxin A (LXA) is a novel eicosanoid, generated by the interactions of lipoxygenases, which has a variety of biological actions. When added to human polymorphonuclear leukocytes, LXA stimulated thromboxane formation which was monitored as TxB2 by radioimmunoassay. The compound augmented the formation of TxA2 stimulated by the ionophore of divalent cations (A23187). Formation of thromboxane was inhibited by two non-steroidal anti-inflammatory drugs (i.e. indomethacin and proglumetacin). Results of the present study indicate that LXA can provoke the release and transformation of endogenous arachidonic acid to thromboxane. Moreover, they suggest a relationship between lipoxin A and the formation of cyclooxygenase pathway products.

【 授权许可】

Unknown