Mesenteric vascular responses to i.v. administration of lipoxin A4 and lipoxin B4 in the conscious rat

FEBS Letters

Feuerstein, Giora¹  Siren, Anna-Leena¹ 

[1] Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA

关键词: Lipoxin;    Anaphylaxis;    Mesenteric circulation;    Renal circulation;    Icosanoid;   

DOI  :  10.1016/0014-5793(88)80384-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipoxin A₄ and lipoxin B₄ are newly discovered lipoxygenase-interacting products of leukocytes which might have a role in cardiovascular events associated with anaphylaxis. We have tested this possibility by systemic administration of both LXA₄ and LXB₄ to the conscious rat while monitoring systemic and regional hemodynamic changes. LXA₄ and LXB₄ (1–100 μg/kg) produced dose-dependent constriction of the mesenteric vessels, up to + 123 ± 23% and + 50 ± 9% for LXA₄/B₄, respectively. Dose-related changes were not observed in arterial blood pressure, heart rate, renal (LXB₄) and hindquarter blood flow. We suggest that LXA₄ and LXB₄ might affect selective vascular beds, such as the mesenteric vessels, and contribute to variations in blood flow in specific pathophysiological states.

【 授权许可】

Unknown