Induction and activation of tissue transglutaminase during programmed cell death

FEBS Letters

Falus, Andras³  Fesus, Laszlo²  Thomazy, Vilmos¹ 

[1] Department of Pathology, University School of Medicine, Debrecen H-4012 National Institute of Rheumatology and Physiotherapy, Budapest H-1525, Hungary;Department of Biochemistry University School of Medicine, Debrecen H-4012 Hungary;Division of Immunology and Molecular Biology, National Institute of Rheumatology and Physiotherapy, Budapest H-1525, Hungary

关键词: Transglutaminase;    mRNA;    ε-(γ-Glutamyl)lysine;    Hepatocyte;    Thymocyte;    Apoptosis;   

DOI  :  10.1016/0014-5793(87)80430-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

During the involution of lead nitrate-induced hyperplasia in rat liver a significant increase of transglutaminase activity, enzyme concentration, transglutaminase messenger RNA and protein-bound ε-(γ-glutamyl)lysine (product of transglutaminase action) coincided with programmed death (apoptosis) of hepatocytes. Immunohistochemical examination showed the appearance of transglutaminase in apoptotic hepatocytes. An increased transglutaminase level was also detected during glucocorticoid-induced apoptosis of rat thymocytes.

【 授权许可】

Unknown