Epidermal growth factor as a new regulator of induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids

FEBS Letters

Katunuma, Nobuhiko¹  Fukusen, Naomi¹  Kido, Hiroshi¹ 

[1] Division of Enzyme Chemistry, The Institute for Enzyme Research, The University of Tokushima, Tokushima 770, Japan

关键词: Glucocorticoid;    Epidermal growth factor;    Enzyme induction;    Hepatocyte;    Adrenalectomy;    TAT;    tyrosine aminotransferase;    TO;    tryptophan 2;    3-dioxygenase;    EGF;    epidermal growth factor;   

DOI  :  10.1016/0014-5793(87)80293-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Epidermal growth factor (EGF) dose-dependently enhanced the induction of tyrosine aminotransferase and tryptophan oxygenase by glucocorticoids in primary cultures of adult rat hepatocytes without itself having any effect on these enzymes in the absence of glucocorticoids. The amplifications were observed even with dexamethasone at high concentrations (10⁻⁶ M−10⁻⁵ M) that had a maximal effect. EGF had no effect on induction of tyrosine aminotransferase by glucagon or Bt₂cAMP. The effect of EGF was also observed in adrenal-ectomized and submaxillar gland-ectomized rats. These results suggest that EGF is an endogenous amplifier of the action of glucocorticoids.

【 授权许可】

Unknown